Repeatability of dynamic <scp>3D</scp> phase?resolved functional lung (PREFUL) ventilation <scp>MR</scp> Imaging in patients with chronic obstructive pulmonary disease and healthy volunteers

Background A previous study has demonstrated the feasibility of 3D phase-resolved functional lung (PREFUL) MRI in healthy volunteers and patients with chronic pulmonary disease. Before clinical use, repeatability ventilation parameters derived from PREFUL must be determined. Purpose To evaluate to compare testing (PFT). Study Type Prospective. Population Fifty-three subjects 13 obstructive disease (COPD). Field Strength/Sequence prototype stack-of-stars spoiled-gradient-echo sequence at 1.5 T. Assessment participants underwent repeated examination (median time interval between scans COPD/healthy [interquartile range]: 7/0 days [6–8/0–0 days]) one PFT carried out baseline MRI. For PREFUL, regional (RVent) flow-volume loops were computed rated by cross-correlation (CC). Also, time-to-peak (VTTP) was computed. Ventilation defect percentage (VDP) maps obtained for RVent CC. Statistical Tests Repeatability evaluated using Bland–Altman analysis, coefficient variation (COV) intraclass correlation (ICC). The relation measures (forced expiratory volume 1 second (FEV1) forced vital capacity (FVC) assessed Pearson (r). Results In COPD patients, no significant bias (all P range: 0.09–0.77) a moderate good RVent, VTTP, VDPRVent found (COV 0.1%–18.2%, ICC 0.51–0.88). CC VDPCC 0.6%–43.6%, ICC: 0.38–0.60). CC, VDPRVent, showed FEV1 |r| > 0.58, all < 0.05) FEV1/FVC ratio 0.62, 0.05). Data Conclusion provided correlated well FEV1/FVC. Level Evidence 2 Technical Efficacy Stage